Manioc : Portail | resultats 1 - 20 pour la recherche: Yu, Hua

La France équinoxiale. [Tome second], Voyage à travers les Guyanes et l'Amazonie
Auteur(s) : Coudreau, Henri Anatole (1859-1899)
Année de publication :

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Dictionaire francois-caraibe
Auteur(s) : Breton, Raymond (1609-1679)
Année de publication :

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Annales de la propagation de la foi. recueil périodique. Des lettres des évêques et des missionnaires des missions des deux mondes, et de tous les documents relatifs aux missions et à l'uvre de la propagation de la foi. Tome vingt-unième
Année de publication :

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Guidelines for the use and interpretation of assays for monitoring autophagy.
Auteur(s) : Klionsky, Daniel J Abdalla, Fabio C Abeliovich, Hagai Abraham, Robert T Acevedo-Arozena, Abraham Adeli, Khosrow Agholme, Lotta Agnello, Maria
Auteurs secondaires : Molecular and Cellular Biology ; University of Leuven Laboratoire d'Epigénétique et Cancer ; CNRS - Université Paris-Sud - Paris 11 (UP11) Department of Pharmacology ; Department of Pharmacology Immunobiologie des Cellules Dendritiques ; INSERM - Institut Pasteur de Paris Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (FEMTO-ST) ; CNRS - Université de Franche-Comté - Université de Technologie de Belfort-Montbeliard - Ecole Nationale Supérieure de Mécanique et des Microtechniques Telethon Institute for Genetics and Medicine ; Telethon Institute Medical Genetics ; Federico II University Department of Molecular and Human Genetics ; Baylor College of Medicine

Éditeur(s) : HAL CCSD Landes Bioscience
Résumé : International audience
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
Autophagy

hal-00735751
https://hal.archives-ouvertes.fr/hal-00735751
PUBMED : 22966490

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Clay mineral evolution in the central Okinawa Trough since 28 ka: Implications for sediment provenance and paleoenvironmental change
Auteur(s) : Dou, Yanguang Yang, Shouye Liu, Zhenxia Clift, Peter D. Yu, Hua Berne, Serge Shi, Xuefa

Éditeur(s) : Elsevier
Résumé : The Okinawa Trough is a natural laboratory for the study of later Quaternary land-ocean interaction and paleoenvironmental changes. In this study we reconstruct the evolution of clay mineral assemblages in Core DGKS9604 retrieved from the central Okinawa Trough. Illite dominates the clay mineral compositions, with average contents above 60%. Clay mineral evolution since 28 ka is closely related to changes in sediment provenance and paleoenvironment. Sea level rise and the strength of the Kuroshio Current control the dispersal and deposition of clays on the East China Sea shelf and in the Okinawa Trough, and thus, determine the clay mineral compositions in the core sediments. During the late last glacial period (28.0-14.0 ka), the paleo-Changjiang River mouth was situated at the shelf edge close to the central Okinawa Trough and thus, together with the outer shelf, supplied large volumes of terrigenous sediments directly into the trough. From 14.0 to 8.4 ka influence from the Changjiang decreased while the mid-outer shelf of the East China Sea became the dominant sediment source to the central Okinawa Trough as sea level rose and the Changjiang river mouth migrated west. Strong sediment reworking and erosion at the shelf edge at 15-13 ka significantly increased the lateral transport of fine-grained shelf sediments to the central Okinawa Trough. Since ca. 8.4 ka clays from Taiwan have dominated the sediment flux to the site, coinciding with the re-entry of the Kuroshio Current into the trough. The increasing influence of the Changjiang-sourced sediments since 1.5 ka was probably related to the weakening of the Kuroshio Current and/or a higher river flux. (C) 2010 Elsevier B.V. All rights reserved.
Palaeogeography, Palaeoclimatology, Palaeoecology (0031-0182) (Elsevier), 2010-03 , Vol. 288 , N. 1-4 , P. 108-117

Droits : 2010 Elsevier B.V. All rights reserved.
http://archimer.ifremer.fr/doc/00002/11367/7977.pdf
DOI:10.1016/j.palaeo.2010.01.040
http://archimer.ifremer.fr/doc/00002/11367/

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